Selected Publications:
Tang, B.; Ghosh, D.; Hoss, W.; Messer, W. Stimulation of a-secretase and Akt by the muscarinic agonist CDD-0102, Society for Neuroscience, Annual Meeting, Poster #296.13, 2003.
Messer, W.S., Jr., K.A. Bachmann, C. Dockery, A.A. El-Assadi, E. Hassoun, N. Haupt, B. Tang and X. Li. Development of CDD-0102 as a selective M1 agonist for the treatment of Alzheimer’s disease. Drug Dev. Res. 57(4): 200-213, 2003.
Cao, Y., M. Zhang, C. Wu, S. Lee, M.E. Wroblewski, T. Whipple, P.I. Nagy, K. Takács-Novák, A. Balázs, S. Tőrös and William S. Messer, Jr. Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders. J. Med. Chem. 46:4273-4286, 2003.
Messer, W.S., Jr., Cholinergic agonists and the treatment of Alzheimer’s disease. Curr. Top. Med. Chem. 2: 353-358, 2002.
Messer, W.S., Jr., The utility of muscarinic agonists in the treatment of Alzheimer’s disease. J. Mol. Neurosci. 19: 187-193, 2002.
Rajeswaran, W.G., Y. Cao, X.-P. Huang, M.E. Wroblewski, T. Colclough, S. Lee, F. Liu, P.I. Nagy, J. Ellis, B.A. Levine, K.H. Nocka and W.S. Messer, Jr. Design, synthesis and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists. J. Med. Chem. 44(26): 4563-4576, 2001.
Messer, W.S., Jr., W.G. Rajeswaran, Y. Cao, H.-J. Zhang, A.A. El-Assadi, C. Dockery, J. Liske, J. O’Brien, F.E. Williams, X.-P. Huang, M.E. Wroblewski, P.I. Nagy and S.M. Peseckis. Design and development of selective muscarinic agonists for the treatment of Alzheimer’s disease: Characterization of tetrahydropyrimidine derivatives and development of new approaches to improved affinity and selectivity for M1 receptors. Pharm. Acta Helv 74(2-3): 135-140, 2000.
Messer, W.S., Jr., Y.F. Abuh, Y. Liu, S. Periyasamy, D.O. Ngur, M.A.N. Edgar, A.A. El-Assadi, S. Sbeih, P.G. Dunbar, S. Roknich, T. Rho, Z. Fang, B. Ojo, H. Zhang, J.J. Huzl, III and P.I. Nagy. Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives as selective m1 agonists. J. Med. Chem. 40: 1230-1246, 1997.
Messer, W.S., Jr., Y.F. Abuh, K. Ryan, M.A. Shepherd, M. Schroeder, S. Abunada and A.A. El-Assadi. Tetrahydropyrimidine derivatives display functional selectivity for M1muscarinic receptors in brain. Drug Dev. Res. 40: 171-174, 1997.
